Search results for " Systeme::004 | Informatik"

Filtered circular fingerprints improve either prediction or runtime performance while retaining interpretability

2016

CheS-Mapper - Chemical Space Mapping and Visualization in 3D

2012

Abstract Analyzing chemical datasets is a challenging task for scientific researchers in the field of chemoinformatics. It is important, yet difficult to understand the relationship between the structure of chemical compounds, their physico-chemical properties, and biological or toxic effects. To that respect, visualization tools can help to better comprehend the underlying correlations. Our recently developed 3D molecular viewer CheS-Mapper (Chemical Space Mapper) divides large datasets into clusters of similar compounds and consequently arranges them in 3D space, such that their spatial proximity reflects their similarity. The user can indirectly determine similarity, by selecting which f…

CUSHAW3: Sensitive and Accurate Base-Space and Color-Space Short-Read Alignment with Hybrid Seeding

2014

The majority of next-generation sequencing short-reads can be properly aligned by leading aligners at high speed. However, the alignment quality can still be further improved, since usually not all reads can be correctly aligned to large genomes, such as the human genome, even for simulated data. Moreover, even slight improvements in this area are important but challenging, and usually require significantly more computational endeavor. In this paper, we present CUSHAW3, an open-source parallelized, sensitive and accurate short-read aligner for both base-space and color-space sequences. In this aligner, we have investigated a hybrid seeding approach to improve alignment quality, which incorp…

Steering Institutionalization through Institutional Work: The Case of an eProcurement System in Indonesian Local Government

2014

Corruption is arguably one of the main hindrances to development. In their effort to combat corruption, governments in developing countries turn to information technology to enhance transparency in decision making. However, implementation of an information system in this context is not straightforward. Premised upon institutional theory, this interpretive case study traces the role of institutional actors in the institutionalization of an eProcurement system in Indonesian local government. It draws on different streams of research on institutional work to develop an interpretive lens to understand what institutional actors do to steer the institutionalization process. It identifies a set of…

Conceptualization for intended action: A dynamic model

2023

Concepts are the building blocks of higher-order cognition and consciousness. Building on Conceptual Spaces Theory (CST) and proceeding from the assumption that concepts are inherently dynamic, this paper provides historical context to and significantly elaborates the previously offered Iterative Subdivision Model (ISDM) with the goal of pushing it toward empirical testability. The paper describes how agents in continuous interaction with their environment adopt an intentional orientation, estimate the utility of the concept(s) applicable to action in the current context, engage in practical action, and adopt any new concepts that emerge: a largely pre-intellectual cycle that repeats essent…

Exploring the Link between ICT and Development in the Context of Developing Countries : A Literature Review

2014

Published version of an article in the journal: Electronic Journal of Information Systems in Developing Countries. Also available from the publisher at: http://www.ejisdc.org/ojs2/index.php/ejisdc/article/view/1332. Open Access The article contributes to the ongoing discussion on relating information and communication technology (ICT) to development (D). The quest to relate ICT to D is a topic of open deliberation and critical scrutiny in ICT4D research communities. To enhance the understanding in this regard, we conducted a literature review. The review examines 80 articles to identify various development theories and the role of technologies in the development process. While scanning the …

Understanding ICT in ICT4D : An Affordance Perspective

2017

Understanding the role of ICT for development is at the core of ICT4D research. However, prevailing research in this field most often focuses on access or readiness of a technology, or on the outcomes of the technology use. Less attention has been paid to understand the mechanism of the technology use that leads to the outcomes. The question of why ICT in a development context sometimes work and sometimes does not work still remains a subject of enquiry. To enhance our understanding in this regard, we propose to use the concept of affordances to unfold the “black boxed” nature of ICT. We revisited a case from Kenya to illustrate the application of affordances in a ICT4D context. The finding…

Dark Design Patterns : An End-User Perspective

2020

The number of websites and mobile applications available is growing continually, as are the persuasive approaches to influence human behavior and decision making. Although designing for persuasion offers several potential benefits, recent developments expose various deceptive designs, that is, dark patterns, that utilize psychological factors to nudge people toward, from someone else’s perspective, desired directions. This paper contributes to an increased awareness of the phenomenon of dark patterns through our exploring how users perceive and experience these patterns. Hence, we chose a qualitative research approach, with focus groups and interviews, for our exploration. Our analysis show…

Digital competence across boundaries - beyond a common Nordic model of the digitalisation of K-12 schools?

2021

This paper explores policy related to digital competence and the digitalisation of Nordic K-12 schools. Anchored in some key transnational policies on digital competence, it describes some current Nordic movements in the national policies of Denmark, Finland, Norway and Sweden. The concept of boundary objects is used as an analytical lens, for understanding digital competence as a plastic and temporal concept that can be used to discuss the multi-dimensional translation of this concept in these Nordic countries. The paper ends with a discussion of the potential to view digital competence as a unifying boundary object that, with its plasticity, temporality and n-dimensionality, can show sign…

Overview of first Wendelstein 7-X high-performance operation

2019

Abstract The optimized superconducting stellarator device Wendelstein 7-X (with major radius , minor radius , and plasma volume) restarted operation after the assembly of a graphite heat shield and 10 inertially cooled island divertor modules. This paper reports on the results from the first high-performance plasma operation. Glow discharge conditioning and ECRH conditioning discharges in helium turned out to be important for density and edge radiation control. Plasma densities of with central electron temperatures were routinely achieved with hydrogen gas fueling, frequently terminated by a radiative collapse. In a first stage, plasma densities up to were reached with hydrogen pellet injec…